Bile Acid Determination after Standardized Glucose Load in Pregnant Women
| Autor: | Virginia R. Lupo, April D. Adams, Rachel Isaksson Vogel, Katherine Jacobs |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Physiology lcsh:Gynecology and obstetrics Article Liver disorder Cholestasis Internal medicine medicine Prospective cohort study lcsh:RG1-991 bile acids Glucose tolerance test Pregnancy medicine.diagnostic_test Bile acid business.industry Obstetrics and Gynecology medicine.disease Endocrinology Pediatrics Perinatology and Child Health Gestation pregnancy business cholestasis liver disease Cholestasis of pregnancy |
| Zdroj: | AJP Reports American Journal of Perinatology Reports, Vol 05, Iss 02, Pp e168-e171 (2015) |
| ISSN: | 2157-7005 2157-6998 |
| Popis: | Objective Intrahepatic cholestasis of pregnancy (ICP) is a rare liver disorder, usually manifesting in the third trimester and associated with increased perinatal morbidity and mortality. The hallmark laboratory abnormality in ICP is elevated fasting serum bile acids; however, there are limited data on whether a nonfasting state affects a pregnant woman's total bile acids. This study assesses fasting and nonfasting bile acid levels in 10 healthy pregnant women after a standardized glucose load to provide insight into the effects of a glucose load on bile acid profiles. Study Design Pilot prospective cohort analysis of serum bile acids in pregnant women. A total of 10 healthy pregnant women from 28 to 32 weeks' gestation were recruited for the study before undergoing a glucose tolerance test. Total serum bile acids were collected for each subject in the overnight fasting state, and 1 and 3 hours after the 100-g glucose load. Results There was a statistically significant difference between fasting versus 3-hour values. There was no statistically significant difference between fasting versus 1-hour and 1-hour versus 3-hour values. Conclusion There is a difference between fasting and nonfasting total serum bile acids after a 100-g glucose load in healthy pregnant women. |
| Databáze: | OpenAIRE |
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