Hypotensive effect of hydroxylamine, an endogenous nitric oxide donor and SSAO inhibitor
| Autor: | H. Vidrio, M. Medina |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Nitroprusside Vascular smooth muscle Vasodilator Agents Blood Pressure Vasodilation Hydroxylamine Pharmacology Nitric Oxide Nitric oxide Methylamines chemistry.chemical_compound Isoniazid medicine Animals Nitric Oxide Donors Enzyme Inhibitors Rats Wistar Biological Psychiatry Dose-Response Relationship Drug biology Methylamine Hydralazine Rats Nitric oxide synthase Psychiatry and Mental health Neurology chemistry Biochemistry Guanylate Cyclase Injections Intravenous biology.protein Amine Oxidase (Copper-Containing) Neurology (clinical) Hypotension Nitric Oxide Synthase Methylene blue medicine.drug |
| Zdroj: | Journal of Neural Transmission. 114:863-865 |
| ISSN: | 1435-1463 0300-9564 |
| DOI: | 10.1007/s00702-007-0702-z |
| Popis: | The endogenous compound hydroxylamine relaxes vascular smooth muscle in vitro, apparently through conversion to the vasodilator factor nitric oxide, but its effect on blood pressure has not been characterized. We found that in the anesthetized rat the amine elicits dose-related hypotension when administered by continuous iv infusion. In experiments designed to explore the mechanism of this effect, hydroxylamine was compared with the nitric oxide donor nitroprusside and the direct-acting vasodilator hydralazine, using pretreatments known to modify diverse mechanisms of vasodilation. Hydroxylamine hypotension was enhanced by the SSAO inhibitor isoniazid and the SSAO substrate methylamine, a pattern shared by hydralazine. Responses were blocked by the guanylate cyclase inhibitor methylene blue and were increased by the nitric oxide synthase inhibitor L-NAME, a pattern shared by nitroprusside. It was concluded that hydroxylamine exerts hypotension partly through conversion to nitric oxide and partly by a "hydralazine-like" mechanism involving SSAO inhibition. |
| Databáze: | OpenAIRE |
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