DCDC2 gene polymorphisms are associated with developmental dyslexia in Chinese Uyghur children
| Autor: | Hua Zhao, Peng-xiang Zuo, Yun Chen, Yi-xin Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
gene polymorphisms Reading disability etiology case-control study Population Single-nucleotide polymorphism Biology elementary school students nerve regeneration developmental dyslexia single nucleotide polymorphisms Xinjiang Uyghur Autonomous Region genetics reading disability neural regeneration lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience DCDC2 medicine Allele education Allele frequency lcsh:Neurology. Diseases of the nervous system Genetics education.field_of_study Haplotype Dyslexia medicine.disease 030104 developmental biology 030217 neurology & neurosurgery Research Article |
| Zdroj: | Neural Regeneration Research, Vol 12, Iss 2, Pp 259-266 (2017) Neural Regeneration Research |
| ISSN: | 1673-5374 |
| Popis: | Developmental dyslexia is a complex reading and writing disorder with strong genetic components. In previous genetic studies about dyslexia, a number of candidate genes have been identified. These include DCDC2, which has repeatedly been associated with developmental dyslexia in various European and American populations. However, data regarding this relationship are varied according to population. The Uyghur people of China represent a Eurasian population with an interesting genetic profile. Thus, this group may provide useful information about the association between DCDC2 gene polymorphisms and dyslexia. In the current study, we examined genetic data from 392 Uyghur children aged 8-12 years old from the Xinjiang Uyghur Autonomous Region of China. Participants included 196 children with dyslexia and 196 grade-, age-, and gender-matched controls. DNA was isolated from oral mucosal cell samples and fourteen single nucleotide polymorphisms (rs6456593, rs1419228, rs34647318, rs9467075, rs793862, rs9295619, rs807701, rs807724, rs2274305, rs7765678, rs4599626, rs6922023, rs3765502, and rs1087266) in DCDC2 were screened via the SNPscan method. We compared SNP frequencies in five models (Codominant, Dominant, Recessive, Heterozygote advantage, and Allele) between the two groups by means of the chi-squared test. A single-locus analysis indicated that, with regard to the allele frequency of these polymorphisms, three SNPs (rs807724, rs2274305, and rs4599626) were associated with dyslexia. rs9467075 and rs2274305 displayed significant associations with developmental dyslexia under the dominant model. rs6456593 and rs6922023 were significantly associated with developmental dyslexia under the dominant model and in the heterozygous genotype. Additionally, we discovered that the T-G-C-T of the four-marker haplotype (rs9295619-rs807701-rs807724-rs2274305) and the T-A of the two-marker haplotype (rs3765502-1087266) were significantly different between cases and controls. Thus, we conclude that DCDC2 gene polymorphisms are associated with developmental dyslexia in Chinese Uyghur children. |
| Databáze: | OpenAIRE |
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