Lady Windermere syndrome in Castile and León
| Autor: | Sara Blanco-Conde, Teresa Nebreda-Mayoral, Cristina Labayru-Echeverría, Ramiro López-Medrano, M. Fe Brezmes-Valdivieso, Begoña Nogueira-González |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Lady Windermere syndrome Pulmonary disease 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Internal medicine Genotype medicine Humans Mycobacterium avium complex Respiratory samples Aged Mycobacterium avium-intracellulare Infection Retrospective Studies Aged 80 and over biology business.industry Retrospective cohort study Syndrome Middle Aged biology.organism_classification 030228 respiratory system Spain Female business Mycobacterium |
| Zdroj: | Enfermedades infecciosas y microbiologia clinica (English ed.). 36:644-647 |
| ISSN: | 2529-993X |
| Popis: | Introduction Lady Windermere syndrome (LWS) is a pulmonary disease caused by Mycobacterium avium complex (MAC). The objective of this study is to ascertain its frequency and characteristics in the northern area of the autonomous community of Castile and Leon. Methods A retrospective study of patients with MAC isolates in respiratory samples from five public hospitals in the autonomous community over a 6-year period, following the ATS/IDSA criteria. The MAC strains were identified by GenoType Mycobacterium reverse hybridisation probes or PCR-RFLP analysis of the hsp65 gene. Results Of 183 cases of MAC identified, only five women (2.7%) aged 68.8 ± 10.7 years met LWS criteria. In three cases, MAC was isolated jointly and intermittently with other pathogens. Only one patient was treated according to ATS/IDSA criteria. Discussion LWS remains underestimated, with affected patients representing a significant burden on healthcare resources over long periods of time. As a result, greater microbiological and therapeutic knowledge of the syndrome is needed. |
| Databáze: | OpenAIRE |
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