Benzofuran-substituted urea derivatives as novel P2Y1 receptor antagonists
| Autor: | Shobha Senadhi, Joseph P. Marino, Cynthia L. Burns-Kurtis, Lorena A. Kallal, Dwight M. Morrow, Reema K. Thalji, Nambi Aiyar, Joseph A. Erhardt, Elizabeth A. Davenport |
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| Rok vydání: | 2010 |
| Předmět: |
Bicyclic molecule
Chemistry Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Platelet Activation Biochemistry Chemical synthesis In vitro Receptors Purinergic P2Y1 chemistry.chemical_compound Drug Discovery Purinergic P2Y Receptor Antagonists Urea Molecular Medicine Potency Platelet activation Benzofuran Receptor Molecular Biology Benzofurans |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 20:4104-4107 |
| ISSN: | 0960-894X |
| Popis: | Benzofuran-substituted urea analogs have been identified as novel P2Y1 receptor antagonists. Structure–activity relationship studies around the urea and the benzofuran moieties resulted in compounds having improved potency. Several analogs were shown to inhibit ADP-mediated platelet activation. |
| Databáze: | OpenAIRE |
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