Toxicity and Outcome of Intensive Chemotherapy for Acute Lymphoblastic Leukemia Complicated with Turner's Syndrome
| Autor: | Shingo Yano, Noriko Usui, Masayuki Kobayashi, Katsuki Sugiyama, Takeshi Saito, Kyoko Ueda, Mamoru Hisatomi, Nobuaki Dobashi, Osamu Asai |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Vincristine
medicine.medical_specialty Adolescent Cyclophosphamide Daunorubicin medicine.medical_treatment Turner Syndrome Gastroenterology Diagnosis Differential Internal medicine Antineoplastic Combined Chemotherapy Protocols Internal Medicine medicine Humans Sex Chromosome Aberrations Chromosomes Human X Chemotherapy Dose-Response Relationship Drug business.industry Remission Induction Induction chemotherapy General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Treatment Outcome Liver Dysplasia Karyotyping Toxicity Immunology Prednisolone Female business Follow-Up Studies medicine.drug |
| Zdroj: | Internal Medicine. 44:145-148 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.44.145 |
| Popis: | A 17-year-old woman was diagnosed as acute lymphoblastic leukemia (ALL). As she had chromosomal abnormalities of 44, XO, der(9)t(3;9)(q11;p13), der(10;19)(q10;p10), del(15)(q15), -16, -19, +22 with the presence of ovarian dysplasia and abnormal physical features, a diagnosis of Turner's syndrome was made. She received an induction chemotherapy, which consisted of daunorubicin, cyclophosphamide, vincristine, L-asparaginase and prednisolone. Although, severe liver dysfunction was observed, the patient achieved a complete remission (CR) on day 31 following chemotherapy and has maintained CR for more than five years. The recording of such cases may well be of value to clarify toxicity and outcome after chemotherapy for patients with ALL complicated with Turner's syndrome. |
| Databáze: | OpenAIRE |
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