Effect of Charcoal and Sorbitol-Charcoal Suspension on the Elimination of Intravenous Phenobarbital
| Autor: | Mary J. Berg, Richard W. Fincham, Dale Eric Wurster, James Q. Rose, Dorothy D. Schottelius, Shaila Rahman |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty Pharmacology Immunoenzyme Techniques chemistry.chemical_compound Suspensions Oral administration medicine Humans Sorbitol Pharmacology (medical) Charcoal Chemistry Crossover study Surgery Phenobarbital visual_art visual_art.visual_art_medium Drug intoxication Half-Life medicine.drug |
| Zdroj: | Therapeutic Drug Monitoring. 9:41-47 |
| ISSN: | 0163-4356 |
| DOI: | 10.1097/00007691-198703000-00008 |
| Popis: | The effects of two different oral charcoal suspensions on the elimination of a 200 mg/70 kg, 1 h intravenous (i.v.) infusion of phenobarbital and the tolerances of the two regimens were determined in a randomized crossover study in six healthy male volunteers. Phenobarbital was given i.v. alone or together with 105 g of oral activated charcoal suspension or with 105 g of a commercially available sorbitol-charcoal suspension over a 36-h period. A 13-34% decrease in the area under the serum concentration time curve (AUC) for 0-60 h occurred with the administration of the activated charcoal, and a 19-52% decrease occurred with the commercial sorbitol-charcoal regimen. The mean apparent systemic clearance of total phenobarbital increased from 0.089 +/- 0.019 ml/min/kg to 0.141 +/- 0.029 and 0.146 +/- 0.036 ml/min/kg with the charcoal and sorbitol-charcoal treatments, respectively. No significant change in the fraction of phenobarbital bound to protein was detected. The charcoal regimen caused constipation in one subject. All subjects taking the sorbitol-charcoal preparation experienced diarrhea; there were no changes in electrolytes with either charcoal suspension. All subjects preferred the sorbitol-charcoal preparation. |
| Databáze: | OpenAIRE |
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