In vitro immunologic studies on a population of workers exposed to phthalic and tetrachlorophthalic anhydride
| Autor: | Dennis K. Flaherty, Ernest Tillman, Mary B. Compas, Peggy Ann Winzenburger, Cindy J. Gross, Kelly L. McGarity |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty Allergy Population Phthalic Acids In Vitro Techniques Immunoglobulin E Lymphocyte Activation Histamine Release chemistry.chemical_compound medicine Humans education Skin Tests education.field_of_study Phthalic anhydride biology business.industry Public Health Environmental and Occupational Health Middle Aged Human serum albumin medicine.disease In vitro Surgery Basophils chemistry Phthalic Anhydrides Toxicity Immunology biology.protein Female business Histamine medicine.drug |
| Zdroj: | Journal of occupational medicine. : official publication of the Industrial Medical Association. 30(10) |
| ISSN: | 0096-1736 |
| Popis: | In vitro radioallergosorbent tests have not been useful in identification of subjects with symptomatic allergic responses to acid anhydrides. By using phthalic anhydride or tetrachlorophthalic anhydride conjugated to human serum albumin, a study was undertaken to determine whether histamine release from basophils or lymphocyte transformation correlated with clinical symptoms, circulating anhydride specific IgE, and skin test reactivity. The data demonstrate that only histamine release from basophils correlated with symptoms and skin test reactivity. We conclude that in vitro histamine assays can be used in the identification of subjects with allergic responses to anhydrides. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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