Early ultrasonographic tumor regression after linear accelerator stereotactic fractionated photon radiotherapy of choroidal melanoma as a predictor for metastatic spread
| Autor: | Ursula Schmidt-Erfurth, Martin Zehetmayer, Andreas Gleiss, Dietmar Georg, Christoph Mitsch, Roman Dunavoelgyi, Karin Dieckmann, Richard Pötter, Ramzi Sayegh |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Uveal Neoplasms Choroidal melanoma medicine.medical_specialty medicine.medical_treatment Brachytherapy Radiosurgery Metastasis 03 medical and health sciences Basal (phylogenetics) Imaging Three-Dimensional 0302 clinical medicine Risk Factors Biomarkers Tumor Tumor regression Humans Medicine Radiology Nuclear Medicine and imaging Risk factor Radionuclide Imaging Melanoma Aged Retrospective Studies Aged 80 and over Photons business.industry Choroid Neoplasms Plaque brachytherapy Area under the curve Radiotherapy Dosage Hematology Middle Aged Prognosis medicine.disease Tumor Burden Radiation therapy Oncology 030220 oncology & carcinogenesis 030221 ophthalmology & optometry Female Dose Fractionation Radiation Radiology Particle Accelerators business |
| Zdroj: | Radiotherapy and Oncology. 127:385-391 |
| ISSN: | 0167-8140 |
| DOI: | 10.1016/j.radonc.2018.04.019 |
| Popis: | BACKGROUND AND PURPOSE During extended follow-up (of up to 15 years), approximately fifty percent of patients with choroidal melanoma will develop metastatic disease and eventually die. Thus, continuing research on prognostic factors, early detection and treatment is necessary. Height regression rates both after plaque brachytherapy and proton beam irradiation have been shown to have prognostic value. The purpose of this study was to analyze the influence of early tumor regression rate after treatment of choroidal melanoma with LINAC stereotactic fractionated radiotherapy (SFRT) as an independent risk factor for metastasis. MATERIAL AND METHODS 256 patients with choroidal melanoma treated with LINAC SFRT were included. Follow-up included standardized echography yielding apical height, smallest and largest basal linear diameter, tumor volume and mean reflectivity. The influence of baseline measurements and of a longitudinal, normalized area under the curve coefficient (NAC) of the latter marker on metastasis risk was assessed. RESULTS NAC for tumor thickness at months 3, 6, and 12 had a statistically significant (p |
| Databáze: | OpenAIRE |
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