Generalized spike-wave discharges involve a default mode network in patients with juvenile absence epilepsy: a MEG study
| Autor: | Fumiya Takeuchi, Naoaki Tanaka, Youji Takeda, Tsugiko Kurita, Hideaki Shiraishi, Tsukasa Koyama, Keitaro Sueda, Kotaro Sakurai, Shingo Nakane |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Precuneus Action Potentials Prefrontal Cortex Electroencephalography Statistical parametric mapping Gyrus Cinguli Juvenile Absence Epilepsy Epilepsy Absence epilepsy medicine Humans Default mode network Generalized spike-wave discharges Cerebral Cortex Brain Mapping medicine.diagnostic_test Dynamic statistical parametric mapping Magnetoencephalography medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Neurology Epilepsy Absence Posterior cingulate Female Neurology (clinical) Psychology Neuroscience |
| Zdroj: | Epilepsy research. 89(2-3) |
| ISSN: | 1872-6844 |
| Popis: | This study uses magnetoencephalography (MEG) to examine whether cortical regions that constitute a default mode network are involved during generalized spike-wave discharges (GSWs) in patients with juvenile absence epilepsy (JAE). We studied five JAE patients for whom MEG was recorded using a 204-channel, whole-head gradiometer system. Dynamic statistical parametric mapping (dSPM) was done to estimate the cortical source distribution of GSW. The dSPM results showed strong medial prefrontal activation in all patients, with activation in the posterior cingulate and precuneus in three of five patients simultaneously or slightly after medial prefrontal activation. Furthermore, dSPM showed that the initial activation of a GSW appears in the focal cortical regions. Cortical regions that constitute a default mode network are strongly involved in the GSW process in some patients with JAE. Results also show that focal cortical activation appears at the onset of a GSW. |
| Databáze: | OpenAIRE |
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