| Autor: |
Aryane A. Vigato, Ian P. Machado, Matheus del Valle, Patricia A. da Ana, Anderson F. Sepulveda, Fabiano Yokaichiya, Margareth K. K. D. Franco, Messias C. Loiola, Giovana R. Tófoli, Cintia Maria S. Cereda, Mirela I. de Sairre, Daniele R. de Araujo |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Pharmaceutics; Volume 14; Issue 2; Pages: 293 |
| ISSN: |
1999-4923 |
| Popis: |
Organogels ORGs are remarkable matrices due to their versatile chemical composition and straightforward preparation. This study proposes the development of ORGs as dual drug carrier systems, considering the application of synthetic monoketonic curcuminoid m CUR and lidocaine LDC to treat topical inflammatory lesions. The monoketone curcuminoid m CUR was synthesized by using an innovative method via a NbCl5 acid catalysis. ORGs were prepared by associating an aqueous phase composed of Pluronic F127 and LDC hydrochloride with an organic phase comprising isopropyl myristate IPM , soy lecithin LEC , and the synthesized m CUR. Physicochemical characterization was performed to evaluate the influence of the organic phase on the ORGs supramolecular organization, permeation profiles, cytotoxicity, and epidermis structural characteristics. The physico chemical properties of the ORGs were shown to be strongly dependent on the oil phase constitution. Results revealed that the incorporation of LEC and m CUR shifted the sol gel transition temperature, and that the addition of LDC enhanced the rheological G amp; 8242; G amp; 8243; ratio to higher values compared to original ORGs. Consequently, highly structured gels lead to gradual and controlled LDC permeation profiles from the ORG formulations. Porcine ear skin epidermis was treated with ORGs and evaluated by infrared spectroscopy FTIR , where the stratum corneum lipids were shown to transition from a hexagonal to a liquid crystal phase. Quantitative optical coherence tomography OCT analysis revealed that LEC and m CUR additives modify skin structuring. Data from this study pointed ORGs as promising formulations for skin delivery |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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