A Versatile Synthesis of 2-Substituted 4-Amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones
| Autor: | Dirk Tourwé, Norbert De Kimpe, Isabelle Van den Eynde, Karolien Van Rompaey |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
chemistry.chemical_classification
integumentary system Peptidomimetic Stereochemistry organic chemicals Organic Chemistry General Medicine Alkylation Biochemistry Reductive amination Benzazepine Amino acid chemistry.chemical_compound chemistry Intramolecular force Drug Discovery Lactam Peptide bond Organic chemistry heterocyclic compounds |
| Zdroj: | ChemInform. 34 |
| ISSN: | 1522-2667 0931-7597 |
| DOI: | 10.1002/chin.200339149 |
| Popis: | A mild and general strategy for the synthesis of 2-substituted 4-amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones is described. The seven-membered lactam is prepared by intramolecular amide bond formation from the intermediate amino acid, which is obtained either by reductive alkylation of a variety of amines with N-Boc,N-Me-ortho-formyl-Phe and Phth-ortho-formyl-Phe, or by reductive amination of a variety of aldehydes with N-Boc-ortho-aminomethyl-Phe. |
| Databáze: | OpenAIRE |
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