Negative pressure wound therapy does not decrease postoperative wound complications in patients undergoing mastectomy and flap fixation
| Autor: | Yvonne L. J. Vissers, S. M. J. van Kuijk, Alfred Janssen, E. R. M. van Haaren, L. de Rooij, Geerard L. Beets, J. van Bastelaar |
|---|---|
| Přispěvatelé: | RS: CAPHRI - R2 - Creating Value-Based Health Care, Epidemiologie, MUMC+: KIO Kemta (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Faculteit FHML Centraal |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Science Breast Neoplasms 030230 surgery Surgical Flaps Article law.invention 03 medical and health sciences 0302 clinical medicine Breast cancer Randomized controlled trial law Negative-pressure wound therapy Surgical Wound Dehiscence medicine Humans Surgical Wound Infection Elective surgery METAANALYSIS SUTURES Mastectomy TISSUE GLUE Aged Wound Healing Multidisciplinary SEROMA FORMATION business.industry Wound dehiscence Skin Transplantation Middle Aged medicine.disease PREVENTION Bandages Surgery Seroma INFECTIONS 030220 oncology & carcinogenesis Surgical oncology Cohort Medicine Female business Negative-Pressure Wound Therapy |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) Scientific Reports Scientific Reports, 11(1):9620. Nature Publishing Group |
| ISSN: | 2045-2322 |
| Popis: | Patients and breast cancer surgeons are frequently confronted with wound complications after mastectomy. Negative pressure wound therapy (NPWT) is a promising technique for preventing wound complications after skin closure in elective surgery. However, a clinical study evaluating postoperative complications following the use of NPWT, focusing solely on closed incisions in patients undergoing mastectomy, has yet to be performed. Between June 2019 and February 2020, 50 consecutive patients underwent mastectomy with NPWT during the first seven postoperative days. This group was compared to a cohort of patients taking part in a randomized controlled trial between June 2014 and July 2018. Primary outcome was the rate of postoperative wound complications, i.e. surgical site infections, wound necrosis or wound dehiscence during the first three postoperative months. Secondary outcomes were the number of patients requiring unplanned visits to the hospital and developing clinically significant seroma (CSS). In total, 161 patients were analyzed, of whom 111 patients in the control group (CON) and 50 patients in the NPWT group (NPWT). Twenty-eight percent of the patients in the NPWT group developed postoperative wound complications, compared to 18.9% in the control group (OR = 1.67 (95% CI 0.77–3.63), p = 0.199). The number of patients requiring unplanned visits or developing CSS was not statistically significant between the groups. This study suggests that Avelle negative pressure wound therapy in mastectomy wounds does not lead to fewer postoperative wound complications. Additionally, it does not lead to fewer patients requiring unplanned visits or fewer patients developing clinically significant seromas.Trial registration: ClinicalTrials.gov number, NCT03942575. Date of registration: 08/05/2019. |
| Databáze: | OpenAIRE |
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