Psychological impact of multigene cancer panel testing in patients with a clinical suspicion of hereditary cancer across Spain

Autor: Estela Carrasco, Francesc Balaguer, Alexandre Teule, Maite Herraiz, C. Alonso-Cerezo, Judith Balmaña, Encarna Adrover, Sonia Servitja, Ariadna Sánchez, R. Serrano, Ana M. Casas, S. Khorrami, S. Gonzalez-Santiago, Antonio Antón, M.J. Oruezábal-Moreno, María José Juan-Fita, Alberto Herreros-de-Tejada, Juana María Cano, A. Angulo, Gemma Llort, Begoña Graña, M.H. López-Ceballos, Joan Brunet, Carmen Guillén-Ponce, J.E. Alés-Martínez, Joaquín Cubiella, Neus Gadea, Teresa Ocaña, Rafael Morales, I. Esteban, I. Garau, Salvador Martinez, M. Vilaró, E. Alba, Lucía Cid, Ana Beatriz Sánchez-Heras, R. Jover
Rok vydání: 2017
Předmět:
0301 basic medicine
Adult
Male
medicine.medical_specialty
Genetic counseling
media_common.quotation_subject
Experimental and Cognitive Psychology
Genetic Counseling
psychology
030105 genetics & heredity
Anxiety
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Internal medicine
Neoplasms
medicine
cancer
Humans
Genetic Predisposition to Disease
Genetic Testing
cancer
genetic counseling
hereditary cancer
multi-gene panels
psychological impact
psychology
Genetic testing
media_common
genetic counseling
medicine.diagnostic_test
business.industry
Cancer
Middle Aged
medicine.disease
Penetrance
Psychiatry and Mental health
Distress
hereditary cancer
Oncology
Spain
030220 oncology & carcinogenesis
Cohort
Hereditary Cancer
Female
psychological impact
Worry
multi-gene panels
business
Zdroj: PSYCHO-ONCOLOGY
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname
r-FISABIO. Repositorio Institucional de Producción Científica
ISSN: 1099-1611
1057-9249
Popis: ObjectivePatients' psychological reactions to multigene cancer panel testing might differ compared with the single-gene testing reactions because of the complexity and uncertainty associated with the different possible results. Understanding patients' preferences and psychological impact of multigene panel testing is important to adapt the genetic counselling model. MethodsOne hundred eighty-seven unrelated patients with clinical suspicion of hereditary cancer undergoing a 25-gene panel test completed questionnaires after pretest genetic counselling and at 1week, 3 months, and 12months after results to elicit their preferences regarding results disclosure and to measure their cancer worry and testing-specific distress and uncertainty. ResultsA pathogenic variant was identified in 38 patients (34 high penetrance and 4 moderate penetrance variants), and 54 patients had at least one variant of uncertain significance. Overall, cancer panel testing was not associated with an increase in cancer worry after results disclosure (P value=.87). Twelve months after results, carriers of a moderate penetrance variant had higher distress and uncertainty scores compared with carriers of high penetrance variants. Cancer worry prior to genetic testing predicted genetic testing specific distress after results, especially at long term (P value
Databáze: OpenAIRE
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