Plasma Endothelin-1 in patients with atrial septal defect – the novel diagnostic indicator (RCD code: IV-2B.1)
| Autor: | Monika Komar, Urszula Gancarczyk, Piotr Wilkołek, Lidia Tomkiewicz‑Pająk, Wojciech Płazak, Tadeusz Przewłocki, Jakub Podolec, Piotr Podolec, Bartosz Sobień |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Percutaneous business.industry medicine.medical_treatment Femoral artery Peripheral medicine.anatomical_structure Blood pressure Ventricle Internal medicine medicine.artery Pulmonary artery Cardiology Medicine Cardiology and Cardiovascular Medicine business Vein Cardiac catheterization |
| Zdroj: | Journal of Rare Cardiovascular Diseases. 2 |
| ISSN: | 2300-5505 2299-3711 |
| DOI: | 10.20418/jrcd.vol2no3.184 |
| Popis: | Background: The study aimed to assess the level of plasma Endothelin-1 (ET-1) in patients before and after transcatheter closure of atrial septal defect (ASD) and to evaluate the usefulness of measuring ET-1 levels for the diagnosis and selection of candidates for ASD closure. Methods: 21 patients (11 F, 10 M), mean age 40.2 ± 11.9 years with pulmonary artery hypertension were enrolled for an attempt at ASD closure. A group of 19 healthy volunteers, (12 F, 7 M) mean age 39.2 ± 9.15 served as controls. All ASD patients underwent: clinical and echocardiographic study and cardiopulmonary exercise test. ET-1 levels were measured before and after closure. Whole blood was collected from femoral artery and vein and from pulmonary artery during cardiac catheterization. Results: ET-1 levels at peripheral artery and vein in ASD patients were significantly higher than in the volunteers (p |
| Databáze: | OpenAIRE |
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