Mechanism-based antitumor screening of Caribbean marine organisms: isolation and structure determination of novel diterpenoids from the gorgonian Eunicea tourneforti
| Autor: | Geetha N. Govindan, Meledath Govindan, David G. I. Kingston |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Magnetic Resonance Spectroscopy
Mutant Pharmaceutical Science Antineoplastic Agents Saccharomyces cerevisiae Analytical Chemistry chemistry.chemical_compound Cnidaria United States Virgin Islands Drug Discovery Bioassay Animals Chromatography High Pressure Liquid Eunicea tourneforti Pharmacology biology Organic Chemistry Isolation (microbiology) biology.organism_classification Terpenoid Yeast Porifera Gorgonian Complementary and alternative medicine Biochemistry chemistry Molecular Medicine Diterpenes Drug Screening Assays Antitumor DNA |
| Zdroj: | Journal of natural products. 58(8) |
| ISSN: | 0163-3864 |
| Popis: | As part of a collaborative research effort between the University of the Virgin Islands and Virginia Polytechnic Institute and State University, we carried out the extraction and bioassay of 87 marine organisms in a mechanism-based assay involving genetically altered yeast strains. Of these, nineteen showed differential activity between the mutant and wild-type yeast strains indicating the presence of potential DNA interacting agents. We now report the isolation and characterization of five new diterpenoids, 2-6, together with the previously known diterpenoid 1, from the bioactive extracts of the gorgonian Eunicea tourneforti forma atra. The structures of the isolated compounds were determined by employing a variety of one- and two-dimensional nmr methods. |
| Databáze: | OpenAIRE |
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