Biomechanical Characterisation of the Human Auricular Cartilages; Implications for Tissue Engineering
| Autor: | Alexander M. Seifalian, Y. Premakumar, M. Szarko, Michelle Griffin, Peter E. M. Butler |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Antihelix 0206 medical engineering Biomedical Engineering Stress–strain 02 engineering and technology Auricular Article Chondrocyte Tissue engineering Ear Cartilage Elastic Modulus otorhinolaryngologic diseases medicine Humans Aged Auricle Tissue Engineering biology business.industry Cartilage Anatomy Middle Aged Human cartilage 021001 nanoscience & nanotechnology Antitragus 020601 biomedical engineering Elastin stomatognathic diseases medicine.anatomical_structure biology.protein Collagen Stress Mechanical 0210 nano-technology business Biomedical engineering |
| Zdroj: | Europe PubMed Central Annals of Biomedical Engineering |
| ISSN: | 1573-9686 0090-6964 |
| DOI: | 10.1007/s10439-016-1688-1 |
| Popis: | Currently, autologous cartilage provides the gold standard for auricular reconstruction. However, synthetic biomaterials offer a number of advantages for ear reconstruction including decreased donor site morbidity and earlier surgery. Critical to implant success is the material’s mechanical properties as this affects biocompatibility and extrusion. The aim of this study was to determine the biomechanical properties of human auricular cartilage. Auricular cartilage from fifteen cadavers was indented with displacement of 1 mm/s and load of 300 g to obtain a Young’s modulus in compression. Histological analysis of the auricle was conducted according to glycoprotein, collagen, and elastin content. The compression modulus was calculated for each part of the auricle with the tragus at 1.67 ± 0.61 MPa, antitragus 1.79 ± 0.56 MPa, concha 2.08 ± 0.70 MPa, antihelix 1.71 ± 0.63 MPa, and helix 1.41 ± 0.67 MPa. The concha showed to have a significantly greater Young’s Elastic Modulus than the helix in compression (p |
| Databáze: | OpenAIRE |
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