Psychological Symptoms Among Patients With BCR-ABL–Negative Myeloproliferative Neoplasms
| Autor: | John Mascarenhas, Marina Kremyanskaya, Heather Polizzi, Ronald Hoffman, Jimmie C. Holland, Daniel C. McFarland |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Cross-sectional study Fusion Proteins bcr-abl Problem list Anxiety 03 medical and health sciences Sex Factors 0302 clinical medicine Polycythemia vera hemic and lymphatic diseases Internal medicine Prevalence medicine Humans 030212 general & internal medicine Myelofibrosis Polycythemia Vera Depression (differential diagnoses) Aged Depression Essential thrombocythemia business.industry Age Factors Middle Aged medicine.disease Antidepressive Agents Distress Cross-Sectional Studies Oncology Primary Myelofibrosis 030220 oncology & carcinogenesis Female medicine.symptom business Stress Psychological Thrombocythemia Essential |
| Zdroj: | Journal of the National Comprehensive Cancer Network. 14:1563-1570 |
| ISSN: | 1540-1413 1540-1405 |
| Popis: | BCR-ABL-negative myeloproliferative neoplasms (MPNs) represent a heterogeneous group of diseases, including essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF). Psychological manifestations among these diseases have not been adequately described.Cross-sectional surveys measuring distress, anxiety, and depression were collected from patients with BCR-ABL-negative MPNs from May 2015 to October 2015. Participants provided demographic information and completed the Distress Thermometer and Problem List (DTPL) to assess distress and the Hospital Anxiety and Depression Scale (HADS) to assess distress, anxiety, and depression. They provided information on how their MPN affected their lives.Of the 117 participants, 31.2% had PV, 28.4% had ET, 28.4% had MF, and 11.9% had another type of MPN. Time with MPN varied from less than 1 year (7.5%), 1 to 3 years (19.8%), 3 to 5 years (23.6%), 5 to 10 years (19.8%), and more than 10 years (29.2%). Distress averaged 3.14 (SD, 2.83; DTPL), with 40.4% meeting NCCN criteria for distress, and averaged 8.97 (SD, 7.44; HADS), with 38.5% meeting HADS criteria for distress. Anxiety averaged 5.54 (SD, 4.37), with 31.3% meeting HADS criteria for anxiety. Depression averaged 3.4 (SD, 3.4), with 12.5% meeting HADS criteria for depression. Distress was higher for PV (3.86), MF (3.12), and "other" MPN (4.33) than it was for ET (1.81; P=.016). Distress was more common in non-white patients (P=.015) and those with either PV or MF but not ET (DTPL ≥4; P=.038). Patients' comments described coping strategies or symptom burden.Distress and anxiety are highly prevalent with BCR-ABL-negative MPNs and may correspond to disease-related symptom burden. These findings deserve further study. |
| Databáze: | OpenAIRE |
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