Testing of cigarette smoke inhalation for teratogenicity in rats
| Autor: | W. Dontenwill, G. Reckzeh, F. Leuschner |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Male
Litter (animal) medicine.medical_specialty Physiology Gestational Age Toxicology Bone and Bones Fetus Pregnancy medicine Animals reproductive and urinary physiology Gynecology Smoke Inhalation business.industry Body Weight Smoking Gestational age Rats Inbred Strains medicine.disease Sperm Rats Teratogens Gestation Female business |
| Zdroj: | Toxicology. 4:355-362 |
| ISSN: | 0300-483X |
| DOI: | 10.1016/0300-483x(75)90051-7 |
| Popis: | The effect of cigarette smoke inhalation on the developing rat embryo was studied. Female rats were exposed to smoke prior to and after mating at miximal tolerated doses. Male rats were ezposed to smoke to prior to mating to investigate the influence upon sperm. On the 21st day of gestation pregnant females of all groups were killed and implantations, litter sizes, foetal resorptions and abortion, foetal weight and length recorded: no significant differences were observed for these parameters between smoke-exposed and control animals. Total maternal wight gain during gestation was lower for smoke-exposed animals than for non-smoke-exposed animals. Examination of foetuses stained according to the method of Frohberg and Oettle resulted in normal variation in the skeletal development in smoke-exposed and control groups as well as in placebo groups. No skeletal malformations could be found.The effects of cigarette smoke inhalation on SIV/50 rats during pregnancy and on their embryos were studied. Also, the effect on male sperm before mating was investigated. From Day 1 of pregnancy, a group of rats were exposed to smoke inhalation. All rats were killed and fetuses removed on Day 21 of gestation. Litter weights, litter sizes, length of fetuses, number of implantation sites, and incidences of resorption in utero were the same in smoke-exposed and control animals. Skeletal development of fetuses was normal in all. Smoke exposure of male rats prior to mating had no observed effect on fetuses. The only effect noted was less body weight gain of the pregnant rats exposed to smoke inhalation. These results are considered only partly applicable to humans. |
| Databáze: | OpenAIRE |
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