Exclusion of Thrombocytopenia as a Contraindication for Invasive Radiofrequency Ablation in a Patient with Paroxysmal Atrial Fibrillation by Using Magnesium Anticoagulation Instead of EDTA: Another Case of Anticoagulant-Induced Pseudo-Thrombocytopenia
| Autor: | Peter Schuff-Werner, Peter Kohlschein, Dietmar Bänsch, Katrin Dreißiger |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Platelet Aggregation
Radiofrequency ablation medicine.drug_class Paroxysmal atrial fibrillation medicine.medical_treatment chemistry.chemical_element Catheter ablation law.invention Magnesium Sulfate Recurrence law Atrial Fibrillation Humans Medicine Platelet Contraindication Edetic Acid Aged Platelet Count business.industry Magnesium Contraindications Anticoagulant Anticoagulants Thrombocytopenia chemistry Radiofrequency catheter ablation Anesthesia Catheter Ablation Female Surgery Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Heart Surgery Forum. 18:090 |
| ISSN: | 1522-6662 1098-3511 |
| DOI: | 10.1532/hsf.1323 |
| Popis: | Thrombocytopenia might be an exclusion criterion for invasive radiofrequency catheter ablation; therefore it is necessary to differentiate between pseudo-thrombocytopenia and a low platelet count due to other etiologies.A 69-year-old female presented to the cardiology department with recurrent atrial fibrillation that was resistant to conventional drug treatment. The initial laboratory findings were within the normal ranges, except for low platelet counts that occurred without a specific bleeding history. The reason for thrombocytopenia was anticoagulant-induced in vitro aggregation of platelets in the presence of EDTA as well as in citrated blood samples. As recently communicated, magnesium anticoagulated blood samples prevent platelet aggregation in individuals with anticoagulant-associated pseudo-thrombocytopenia. Although its aggregation-inhibiting effect is known from previous clinical observations, magnesium sulphate has not been introduced as an anticoagulant in analytical medicine.Based on our observations, blood anticoagulated with magnesium sulphate is recommended to verify low routine platelet counts before final clinical decisions are made. |
| Databáze: | OpenAIRE |
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