Impaired visual working memory and reduced connectivity in undergraduates with a history of mild traumatic brain injury
| Autor: | Nicholas G. Murray, Marian E. Berryhill, Adelle G B Cerreta, Alexandrea Kilgore-Gomez, Hector Arciniega, Sarah Furlong, Jorja Shires |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Traumatic brain injury Science Audiology Electroencephalography Article 050105 experimental psychology Learning and memory Young Adult 03 medical and health sciences 0302 clinical medicine Human behaviour Concussion medicine Humans Psychology Cognitive Dysfunction 0501 psychology and cognitive sciences Students Brain Concussion Default mode network Memory Disorders Multidisciplinary medicine.diagnostic_test Resting state fMRI Working memory 05 social sciences Cognition medicine.disease Memory Short-Term Medicine Female Disconnection Cognition Disorders 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-021-80995-1 |
| Popis: | Mild traumatic brain injury (mTBI), or concussion, accounts for 85% of all TBIs. Yet survivors anticipate full cognitive recovery within several months of injury, if not sooner, dependent upon the specific outcome/measure. Recovery is variable and deficits in executive function, e.g., working memory (WM) can persist years post-mTBI. We tested whether cognitive deficits persist in otherwise healthy undergraduates, as a conservative indicator for mTBI survivors at large. We collected WM performance (change detection, n-back tasks) using various stimuli (shapes, locations, letters; aurally presented numbers and letters), and wide-ranging cognitive assessments (e.g., RBANS). We replicated the observation of a general visual WM deficit, with preserved auditory WM. Surprisingly, visual WM deficits were equivalent in participants with a history of mTBI (mean 4.3 years post-injury) and in undergraduates with recent sports-related mTBI (mean 17 days post-injury). In seeking the underlying mechanism of these behavioral deficits, we collected resting state fMRI (rsfMRI) and EEG (rsEEG). RsfMRI revealed significantly reduced connectivity within WM-relevant networks (default mode, central executive, dorsal attention, salience), whereas rsEEG identified no differences (modularity, global efficiency, local efficiency). In summary, otherwise healthy current undergraduates with a history of mTBI present behavioral deficits with evidence of persistent disconnection long after full recovery is expected. |
| Databáze: | OpenAIRE |
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