Treatment of Vitiligo with a Topical Application of Pseudocatalase and Calcium in Combination with Short-Term UVB Exposure: A Case Study on 33 Patients
| Autor: | J. M. Wood, K. R. Lemke, Karin U. Schallreuter, C. Levenig |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Monoamine Oxidase Inhibitors Adolescent Vitiligo chemistry.chemical_element Pseudocatalase Pilot Projects Skin Pigmentation Dermatology Calcium Administration Cutaneous Ultraviolet therapy Depigmentation medicine Humans Child skin and connective tissue diseases Pigmentation disorder Aged Light exposure integumentary system business.industry Remission Induction Follow up studies Hydrogen Peroxide Middle Aged Catalase medicine.disease Photochemotherapy chemistry Child Preschool Female Ultraviolet Therapy medicine.symptom business Follow-Up Studies |
| Zdroj: | Dermatology. 190:223-229 |
| ISSN: | 1421-9832 1018-8665 |
| Popis: | Thirty-three patients with the depigmentation disorder vitiligo were successfully treated with a new topical application of pseudocatalase, calcium and short-term UVB light exposure. First repigmentation occurred in the majority of cases after 2-4 months. Complete repigmentation on the face and dorsum of the hands appeared in 90% of the group. In all patients, active depigmentation was arrested. None of them developed new lesions during treatment. No recurrence of the disease was observed during a 2-year follow-up. The rationale for this pilot study originated from a recent understanding of vitiligo at the molecular level. The involved epidermis produces hydrogen peroxide due to defective tetrahydrobiopterin recycling and increased monoamine oxidase A activity, whereupon catalase is inactivated. In addition, calcium homeostasis is perturbed in the affected skin. The substitution for insufficient catalase by a pseudocatalase together with calcium and UVB exposure lead to effective repigmentation. |
| Databáze: | OpenAIRE |
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