Life-Threatening Complications of Hepatitis B Virus-Related Polyarteritis Nodosa Developing Despite Interferon-α2b Therapy: Successful Treatment with a Combination of Interferon, Lamivudine, Plasma Exchanges and Steroids
| Autor: | P. Stadler, E. Hecker, E. Descombes, G. Schrago, C. Chizzolini, P. Dele´aval, C. Regamey, P. Pugin, A. Nicole |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Hepatitis B virus medicine.medical_specialty Critical Illness Interferon alpha-2 medicine.disease_cause Risk Assessment Rheumatology Interferon Internal medicine Humans Medicine Plasma Exchange business.industry Polyarteritis nodosa Interferon-alpha Lamivudine General Medicine Hepatitis B medicine.disease Combined Modality Therapy Recombinant Proteins Immune complex Polyarteritis Nodosa Treatment Outcome Viral replication Immunology Disease Progression Drug Therapy Combination Female Steroids business Vasculitis Follow-Up Studies medicine.drug |
| Zdroj: | Clinical Rheumatology. 20:290-292 |
| ISSN: | 1434-9949 0770-3198 |
| DOI: | 10.1007/s100670170050 |
| Popis: | Polyarteritis nodosa (PAN) is a rare vasculitis associated with hepatitis B virus (HBV) infection in a significant proportion of cases. When used to treat HBV-related PAN, immunosuppressive agents may enhance viral replication and relaspes are frequent. In recent years the use of antiviral drugs has been proposed. We report the case of a patient with HBV-related PAN who, despite 6 weeks of interferon-alpha2b (IFN-alpha2b) monotherapy, developed life-threatening complications with bowel perforation. He was thereafter successfully treated with a combination of IFN-alpha2b, lamivudine, plasma exchanges and short-term steroids. In contrast to IFN-alpha2b, lamivudine is effective in rapidly suppressing viral replication. This may be valuable in the treatment of HBV-related PAN by contributing to a faster diminution of circulating immune complex levels. This case report highlights the importance of aggressive combined therapy in patients with HBV-related PAN. |
| Databáze: | OpenAIRE |
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