Early intake of long-chain polyunsaturated fatty acids preserves brain structure and function in diet-induced obesity

Autor: Martina P. C. Mutsaers, Ilse A.C. Arnoldussen, Simone Bolijn, Arend Heerschap, Valerio Zerbi, Teake Kooistra, Amanda J. Kiliaan, Rikko H.J. Noordman, Marieke H. Schoemaker, Eric A.F. van Tol, Peter Y. Wielinga, Gabriele Gross, Maximilian Wiesmann, Robert Kleemann, Pieter J. Dederen
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Apolipoprotein E
medicine.medical_specialty
Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1]
Long-chain polyunsaturated fatty acids
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Neuroimaging
White adipose tissue
Biology
Biochemistry
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Urological cancers Radboud Institute for Molecular Life Sciences [Radboudumc 15]
medicine
Brain structure
Animals
Weaning
Obesity
Molecular Biology
chemistry.chemical_classification
Nutrition and Dietetics
Brain
food and beverages
High-fat and high-carbohydrate diets
Lipid metabolism
medicine.disease
Diet
030104 developmental biology
Endocrinology
chemistry
Docosahexaenoic acid
Fatty Acids
Unsaturated
Arachidonic acid
lipids (amino acids
peptides
and proteins)
030217 neurology & neurosurgery
Polyunsaturated fatty acid
Zdroj: Journal of Nutritional Biochemistry, 30, 177-88
Journal of Nutritional Biochemistry, 30, 177-188
Journal of Nutritional Biochemistry 30 (2016)
Journal of Nutritional Biochemistry, 30, pp. 177-88
ISSN: 0955-2863
Popis: Item does not contain fulltext Worldwide, the incidence of obesity is increasing at an alarming rate, and the number of children with obesity is especially worrisome. These developments raise concerns about the physical, psychosocial and cognitive consequences of obesity. It was shown that early dietary intake of arachidonic acid (ARA) and docosahexaenoic acid (DHA) can reduce the detrimental effects of later obesogenic feeding on lipid metabolism and adipogenesis in an animal model of mild obesity. In the present study, the effects of early dietary ARA and DHA on cognition and brain structure were examined in mildly obesogenic ApoE*3Leiden mouse model. We used cognitive tests and neuroimaging during early and later life. During their early development after weaning (4-13weeks of age), mice were fed a chow diet or ARA and DHA diet for 8 weeks and then switched to a high-fat and high-carbohydrate (HFHC) diet for 12weeks (14-26weeks of age). An HFHC-diet led to increased energy storage in white adipose tissue, increased cholesterol levels, decreased triglycerides levels, increased cerebral blood flow and decreased functional connectivity between brain regions as well as cerebrovascular and gray matter integrity. ARA and DHA intake reduced the HFHC-diet-induced increase in body weight, attenuated plasma triglycerides levels and improved cerebrovasculature, gray matter integrity and functional connectivity in later life. In conclusion, an HFHC diet causes adverse structural brain and metabolic adaptations, most of which can be averted by dietary ARA and DHA intake early in life supporting metabolic flexibility and cerebral integrity later in life.
Databáze: OpenAIRE
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