The haemodynamic effects and pharmacokinetics of intravenous nicorandil in healthy volunteers
| Autor: | A. E. Hearron, J. J. Ferry, Daniel L. Wolf, M. O. Froeschke, J. R. Luderer |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Niacinamide Supine position Adolescent Vasodilator Agents Posture Cmax Hemodynamics Blood Pressure Electrocardiography Heart Rate Heart rate medicine Humans Single-Blind Method Pharmacology (medical) Infusions Intravenous Nicorandil Pharmacology Volume of distribution business.industry General Medicine Middle Aged Crossover study Blood pressure Anesthesia Female business medicine.drug |
| Zdroj: | European Journal of Clinical Pharmacology. 44:27-33 |
| ISSN: | 1432-1041 0031-6970 |
| Popis: | We have studied the effects of intravenous nicorandil, a mixed arterial and venous vasodilator, in 48 healthy volunteers. Nicorandil (20, 28, 39, 54, 74, 103, 144, or 200 μg·kg−1) or placebo were given over 5 min to subjects supine (16 subjects, 2 doses) or sitting (32 subjects, 1 dose) in a single-blind crossover design. Electro-cardiographic intervals, blood pressure, and heart rate were measured before and for 8 h after dosing. Blood and urine safety laboratory studies were also performed before and after dosing. All intravenous infusions of nicorandil and placebo were well tolerated and there were no clinically important safety concerns. The most frequent adverse event after nicorandil was headache (24 events by 19 subjects), although its occurrence was not strictly dose related. One subject experienced transient symptomatic hypotension (144 μg·kg−1). Mean plasma nicorandil concentrations were dose-related and fell with a half-life of 0.7 to 1.2 h. Systemic clearance and volume of distribution tended to decrease as dose increased. Sitting subjects showed marginally lower ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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