Early blood pressure level as a mark of familial aggregation of metabolic cardiovascular risk factors--the Rio de Janeiro Study
| Autor: | Celia Szwarcwald, Maria Eliane Campos Magalhães, Ayrton Pires Brandão, Ana L.S. Rousoulieres, Rita C.O. Cerqueira, Roberto Pozzan, Andréa Araujo Brandão |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Longitudinal study Percentile Adolescent Physiology Population Blood Pressure Risk Factors Internal medicine Internal Medicine Medicine Humans Longitudinal Studies Risk factor education Child education.field_of_study business.industry Family aggregation Middle Aged medicine.disease Obesity Lipids Surgery Blood pressure Cardiovascular Diseases Female Cardiology and Cardiovascular Medicine business Body mass index Brazil |
| Zdroj: | Journal of hypertension. 16(12 Pt 2) |
| ISSN: | 0263-6352 |
| Popis: | Objective To investigate the familial aggregation of metabolic risk factors (RF) according to blood pressure (BP) percentile of children and adolescents. Design and methods Normal BP was established in 3906 children and adolescents in 1987. From this population two groups of target individuals were separated: group A (n = 327) with systolic and/or diastolic BP percentile > 95 and group B (n = 327) with systolic and diastolic BP percentile ≤ 50. Ten years later, familial aggregation of metabolic RF was evaluated using clinical and laboratorial data from 785 individuals, divided into two groups: group 1 with 135 target individuals (BP percentile > 95), 181 parents, 100 siblings and 16 grandparents; and group 2: 106 target individuals (BP percentile ≤ 50), 145 parents, 84 siblings and 18 grandparents. Results (1) The longitudinal study 10 years later (tracking effect) showed that 34.8% of target individuals of group 1 and 90.5% of group 2 remained at the same BP percentile. (2) Comparing the two groups of target individuals, group 1 had higher weight and body mass index (BMI), systolic BP (SBP), diastolic BP (DBP), and heart rate (HR) (P < 0.001) and lower HDL (P < 0.003). (3) Comparing target individuals' and their relatives' measurements together, group 1 had higher BMI, HR, SBP, DBP (P < 0.03) and lower HDL (P < 0.001). (4) SBP and DBP showed significant correlation with all metabolic variables even when BMI was controlled in a multiple regression analysis (P < 0.04). Conclusion BP level in children and adolescents was a good marker for familial aggregation of metabolic RF, suggesting an interaction of genetic and environmental factors. Primary intervention should be carried out in early stages of life. |
| Databáze: | OpenAIRE |
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