Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy
| Autor: | Abdullah I. El-Kholy, Rosaline Ashraf, Eman Soliman Metwally, Tarek Erfan, Maha Fadel, Salma A. Bayoumy, Noha A. Ghonim, Abdelkader A. Metwally, Rania M. Hathout, Sherweit H. El-Ahmady, John G. Hardy |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Allicin
Chemistry Pharmaceutical Science Nanoparticle 02 engineering and technology Photothermal therapy Conjugated system 010402 general chemistry 021001 nanoscience & nanotechnology medicine.disease Polypyrrole 01 natural sciences In vitro 0104 chemical sciences Hep G2 chemistry.chemical_compound medicine Biophysics 0210 nano-technology Liver cancer |
| DOI: | 10.1016/j.jddst.2018.07.002 |
| Popis: | We report the development of dual stimuli-responsive nanoparticles with potential for anticancer therapy. The nanoparticles are composed of a conjugated polymer (polypyrrole, PPY) loaded with an anticancer drug (allicin), and were characterized by a variety of physicochemical techniques. The dual stimuli-responsive nature of the PPY nanoparticles was validated in vitro: the PPY nanoparticles delivered an anticancer drug (allicin) in response to exposure to an electric field in vitro as demonstrated with UV–vis spectroscopy; and the PPY nanoparticles exhibited photothermal activity upon irradiation with near infrared light which resulted in resulted in toxicity towards HEP G2 cells in vitro. We believe that such nanoparticles have long term potential for application in cancer therapy in a variety of tissue niches (e.g. breast cancer, liver cancer, lung cancer, skin cancer). |
| Databáze: | OpenAIRE |
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