HLA-A, B, Cw, DRB1, DQB1 and DPB1 alleles and haplotypes in the genetically homogenous Irish population
| Autor: | John Crowley, R. Hagan, C. Dunne, Emer Lawlor, G. Rooney |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
HLA-DP Antigens
Immunology Population HLA-C Antigens Human leukocyte antigen Histocompatibility Testing Biology law.invention Gene Frequency Bone Marrow HLA Antigens law HLA-DQ Antigens Genetics Cluster Analysis HLA-DQ beta-Chains Humans Allele education Molecular Biology Allele frequency Genetics (clinical) Polymerase chain reaction education.field_of_study HLA-A Antigens Haplotype HLA-DR Antigens General Medicine HLA-A Genetics Population Haplotypes HLA-B Antigens Ireland HLA-DRB1 Chains |
| Zdroj: | International Journal of Immunogenetics. 35:295-302 |
| ISSN: | 1744-313X 1744-3121 |
| Popis: | The frequencies of human leucocyte antigen (HLA) class I and II alleles and haplotypes of 250 Irish unrelated bone marrow donors were determined by high resolution polymerase chain reaction (PCR), using a combination of reverse line blot hybridization and PCR with sequence-specific primers. Phylogenetic analyses indicate that this Irish population is closely related to British, North-western European, American and Australian Caucasian populations. These observations are consistent with recognized historical, geographical, cultural, ethnic and linguistic relationships between these populations and suggest that Irish haematopoietic stem cell transplant recipients have a greater likelihood of finding a phenotypically matched donor within registries based on these populations. HLA-A, B, Cw, DRB1, DQB1 and DPB1 analysis confirms that this young homogenous population is characterized by features of a North-western European anthropological type with limited influence of additional ethnic haplotypes. |
| Databáze: | OpenAIRE |
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