Comparative study of the effects of venlafaxine and duloxetine on chemotherapy-induced peripheral neuropathy
| Autor: | Nasrin Moradian, Avisa Alavi, Sahel Heydarheydari, Negin Farshchian |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Cancer Research Gabapentin Venlafaxine Antineoplastic Agents Toxicology Placebo Duloxetine Hydrochloride 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Double-Blind Method Neoplasms medicine Duloxetine Humans Pharmacology (medical) Serotonin and Noradrenaline Reuptake Inhibitors Pharmacology business.industry Therapeutic effect Venlafaxine Hydrochloride Peripheral Nervous System Diseases Middle Aged medicine.disease Peripheral neuropathy Treatment Outcome Oncology chemistry Chemotherapy-induced peripheral neuropathy 030220 oncology & carcinogenesis Anesthesia Neuropathic pain Neuralgia Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Cancer chemotherapy and pharmacology. 82(5) |
| ISSN: | 1432-0843 |
| Popis: | One of the complications of chemotherapy is peripheral neuropathy. Various studies have shown that potent norepinephrine and serotonin reuptake inhibitors such as gabapentin, venlafaxine and duloxetine have therapeutic effects on neuropathy. The aim of this study was to compare the effects of venlafaxine vs. duloxetine on chemotherapy-induced peripheral neuropathy. In this clinical trial, cancer patients who were suffering from chemotherapy-induced peripheral neuropathy comprised the study population. They were randomly assigned to three pharmacotherapy groups including venlafaxine, duloxetine and placebo. Cranial, sensory, motor neuropathies as well as neuropathic pain were evaluated on day 1, week 2, and week 4 after enrollment. Grade of cranial, motor, sensory and neuropathic pain decreased significantly in venlafaxine and duloxetine groups. This reduction was more considerable in duloxetine group compared to venlafaxine group (P |
| Databáze: | OpenAIRE |
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