Lower Levels of Cervicovaginal Tryptophan Are Associated With Natural Clearance of Chlamydia in Women
| Autor: | William M. Geisler, Stephen Barnes, Ladraka' T. Brown, Taylor F. Berryhill, Christen G. Press, Rakesh K. Bakshi, Landon Wilson, Stephen J. Jordan, Kristin M. Olson |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Adolescent Physiology Chlamydia trachomatis Azithromycin 03 medical and health sciences chemistry.chemical_compound Interferon-gamma Young Adult Extracellular Immunology and Allergy Medicine Humans Indole test Chlamydia business.industry Brief Report Tryptophan Chlamydia Infections Middle Aged medicine.disease In vitro 030104 developmental biology Infectious Diseases chemistry Vaginal Douching Female Growth inhibition business Intracellular Clearance |
| Zdroj: | The Journal of infectious diseases. 215(12) |
| ISSN: | 1537-6613 |
| Popis: | Chlamydia trachomatis (Ct) infection causes significant morbidity. In vitro studies demonstrate that Ct growth inhibition occurs by interferon-gamma (IFN-γ)–mediated depletion of intracellular tryptophan, and some Ct strains utilize extracellular indole to restore tryptophan levels. Whether tryptophan levels are associated with Ct infection clearance in humans remains unknown. We evaluated tryptophan, indole, and IFN-γ levels in cervicovaginal lavages from women with either naturally cleared or persisting Ct infection. Women who cleared infection had significantly lower tryptophan levels and trended toward lower IFN-γ levels compared to women with persisting infection. Due to its volatility, indole was not measurable in either group. |
| Databáze: | OpenAIRE |
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