Multifactorial analysis of effects of interactions among antifungal and antineoplastic drugs on inhibition of Candida albicans growth
| Autor: | M. S. Motawy, Mahmoud A Ghannoum, Ashraf S. Ibrahim, R. S. Criddle, M. A. Abu Hatab |
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| Rok vydání: | 1989 |
| Předmět: |
Antifungal
Drug Antifungal Agents medicine.drug_class media_common.quotation_subject Antineoplastic Agents Microbial Sensitivity Tests Pharmacology Biology chemistry.chemical_compound Multifactorial analysis Candida albicans medicine Pharmacology (medical) media_common Drug Synergism biology.organism_classification In vitro Infectious Diseases chemistry Antineoplastic Drugs Growth inhibition Antagonism Research Article |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 33:717-725 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Interactions among antineoplastic and antifungal drugs affecting the inhibition of Candida albicans growth are complex functions of the nature of the drugs used in combination, their absolute concentrations, and also their relative concentrations. Studies of drug interactions involving the use of test drugs in fixed concentration ratios can lead to inaccurate conclusions about synergism or antagonism among the drugs. A multifactorial experimental design procedure in which the concentrations of all drugs in test combinations were simultaneously varied has been used to identify and quantify drug interactions. The methods have been applied to combinations of two, three, and four drugs, including antineoplastic drugs, antifungal drugs, and combinations of antineoplastic and antifungal drugs. Results were obtained which allow predictions of effects of combinations and provide maximum effectiveness in growth inhibition with minimum levels of the test drugs. |
| Databáze: | OpenAIRE |
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