Traumatic Cerebral Microbleeds in the Subacute Phase Are Practical and Early Predictors of Abnormality of the Normal-Appearing White Matter in the Chronic Phase
| Autor: | A.W. van der Eerden, Bozena Goraj, Rashindra Manniesing, Priya Vart, Bram Platel, Vincent Perlbarg, Pieter E. Vos, L. Puybasset, T.L.A. van den Heuvel, Damien Galanaud |
|---|---|
| Přispěvatelé: | Radiology & Nuclear Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Moderate to severe Emergency Medical Services medicine.medical_specialty Subacute phase Traumatic brain injury Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] Corpus callosum Corpus Callosum 030218 nuclear medicine & medical imaging White matter 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine Brain Injuries Traumatic Healthy volunteers medicine Humans Radiology Nuclear Medicine and imaging Cerebral Hemorrhage Retrospective Studies business.industry Adult Brain Prognosis medicine.disease White Matter Healthy Volunteers Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging medicine.anatomical_structure Acute Disease Chronic Disease Cardiology Female Neurology (clinical) Renal disorders Radboud Institute for Health Sciences [Radboudumc 11] Abnormality business 030217 neurology & neurosurgery Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] |
| Zdroj: | AJNR American Journal of Neuroradiology, 42, 861-867 American Journal of Neuroradiology, 42(5), 861-867. American Society of Neuroradiology AJNR Am J Neuroradiol AJNR American Journal of Neuroradiology, 42, 5, pp. 861-867 |
| ISSN: | 0195-6108 |
| Popis: | Contains fulltext : 235370.pdf (Publisher’s version ) (Closed access) BACKGROUND AND PURPOSE: In the chronic phase after traumatic brain injury, DTI findings reflect WM integrity. DTI interpretation in the subacute phase is less straightforward. Microbleed evaluation with SWI is straightforward in both phases. We evaluated whether the microbleed concentration in the subacute phase is associated with the integrity of normal-appearing WM in the chronic phase. MATERIALS AND METHODS: Sixty of 211 consecutive patients 18 years of age or older admitted to our emergency department ≤24 hours after moderate to severe traumatic brain injury matched the selection criteria. Standardized 3T SWI, DTI, and T1WI were obtained 3 and 26 weeks after traumatic brain injury in 31 patients and 24 healthy volunteers. At baseline, microbleed concentrations were calculated. At follow-up, mean diffusivity (MD) was calculated in the normal-appearing WM in reference to the healthy volunteers (MD(z)). Through linear regression, we evaluated the relation between microbleed concentration and MD(z) in predefined structures. RESULTS: In the cerebral hemispheres, MD(z) at follow-up was independently associated with the microbleed concentration at baseline (left: B = 38.4 [95% CI 7.5-69.3], P = .017; right: B = 26.3 [95% CI 5.7-47.0], P = .014). No such relation was demonstrated in the central brain. MD(z) in the corpus callosum was independently associated with the microbleed concentration in the structures connected by WM tracts running through the corpus callosum (B = 20.0 [95% CI 24.8-75.2], P < .000). MD(z) in the central brain was independently associated with the microbleed concentration in the cerebral hemispheres (B = 25.7 [95% CI 3.9-47.5], P = .023). CONCLUSIONS: SWI-assessed microbleeds in the subacute phase are associated with DTI-based WM integrity in the chronic phase. These associations are found both within regions and between functionally connected regions. |
| Databáze: | OpenAIRE |
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