Online adaptive MR-guided stereotactic radiotherapy for unresectable malignancies in the upper abdomen using a 1.5T MR-linac
| Autor: | M.P.W. Intven, Lois A. Daamen, William A. Hall, Gerrit A. Meijer, I. van Goor, H.D. Heerkens, Beth Erickson, Helena M. Verkooijen, H.C. van Santvoort, H. Eijkelenkamp, I.Q. Molenaar, S. de Mol van Otterloo |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Mr linac Hepatology business.industry Endocrinology Diabetes and Metabolism Radiotherapy Planning Computer-Assisted Gastroenterology Hematology General Medicine Radiosurgery Stereotactic radiotherapy Oncology Abdominal Neoplasms Abdomen medicine Humans Radiology Nuclear Medicine and imaging Radiology Prospective Studies Upper abdomen business Mri guided Radiotherapy Image-Guided |
| Zdroj: | Acta oncologica (Stockholm, Sweden). 61(1) |
| ISSN: | 1651-226X |
| Popis: | Introduction of online adaptive MR-guided radiotherapy enables stereotactic body radiation therapy (SBRT) of upper abdominal tumors. This study aimed to evaluate the feasibility of MR-guided SBRT on a 1.5 T MR-linac in patients with unresectable upper abdominal malignancies.Patients treated at the UMC Utrecht (April 2019 to December 2020) were identified in the prospective 'Multi-OutcoMe EvaluatioN of radiation Therapy Using the MR-linac' (MOMENTUM) study. Feasibility of treatment was arbitrarily defined as an on-table time interval of ≤60 min for75% of delivered fractions and completion of95% of fractions as scheduled, reflecting patient tolerability. Acute treatment-related toxicity was assessed at 3 months of follow-up and graded according to the National Cancer Institute Common Terminology Criteria of Adverse Events version 5.0.Twenty-five consecutive patients with a median follow-up time of 8 (range 4-23) months were treated with 35 Gray (Online adaptive MR-guided SBRT on a 1.5 T MR-linac is feasible and well-tolerated in patients with unresectable upper abdominal malignancies. Dose escalation studies, followed by comparative studies, are needed to determine the optimal radiation dose for irradiation of upper abdominal malignancies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|