Updates on bacterial resistance and empirical antibiotics treatment of complicated acute appendicitis in children
| Autor: | Chun Pong Daniel Kwok, Siu Yan Bess Tsui, Kin Wai Chan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Antibiotics medicine.disease_cause Tazobactam 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Antibiotic resistance 030225 pediatrics Internal medicine Escherichia coli medicine Humans Child Retrospective Studies business.industry Pseudomonas aeruginosa Bacterial Infections General Medicine Appendicitis Anti-Bacterial Agents Clinical research chemistry 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Surgery Gentamicin business Ertapenem Piperacillin medicine.drug |
| Zdroj: | Journal of Pediatric Surgery. 56:1145-1149 |
| ISSN: | 0022-3468 |
| DOI: | 10.1016/j.jpedsurg.2021.03.027 |
| Popis: | Objective: Through historical comparison with our previous study published 10 years ago, this paper aims to provide latest analysis of local bacteriology of acute complicated appendicitis and evaluate the effects of early escalation of potent antibiotics on course of postoperative recovery. Methods: A 5-year retrospective review of all children receiving emergency laparoscopic appendicectomies for acute appendicitis from December 2014 to November 2019 was conducted. Results: 257 cases of acute appendicitis were included, 126 were complicated appendicitis (38 gangrenous, 88 ruptured). 96 had positive peritoneal swab culture, 53 (42.1%) grew resistant bacterial strains, including extended spectrum beta-lactamase producing E. coli (ESBL E. coli), Pseudomonas aeruginosa, against traditional empirical triple antibiotics. The prevalence had significantly increased over the past decade (p = 0.008). In our patients, piperacillin/tazobactam, ertapenem, gentamicin provided coverage of 69.8%, 45.3% and 45.3% respectively. For patients with early escalation of postoperative antibiotics, no statistical significance was identified in terms of postoperative complications (p = 0.883), or duration of antibiotics (p = 0.0615). Conclusion: Growing prevalence of resistant strains were observed over the decade. Piperacillin/tazobactam provided the best coverage (69.8%) against resistant bacterial strains in our patients. Early escalation of antibiotics failed to reduce postoperative complications and antibiotics duration. Type of Study: Clinical Research, Retrospective Historical Comparative Study Level of Evidence: Level III |
| Databáze: | OpenAIRE |
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