Immune complexome analysis of antigens in circulating immune complexes isolated from patients with IgG4-related dacryoadenitis and/or sialadenitis
| Autor: | Miyako Baba, Kaname Ohyama, Kunihiro Ichinose, Naoya Kishikawa, Hiroki Takahashi, Motohisa Yamamoto, Naotaka Kuroda, Mami Tamai, Atsushi Kawakami |
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| Rok vydání: | 2015 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Antigen-Antibody Complex Sialadenitis Dacryocystitis 03 medical and health sciences 0302 clinical medicine Mixed connective tissue disease Rheumatology Antigen parasitic diseases medicine Humans skin and connective tissue diseases Aged Aged 80 and over 030203 arthritis & rheumatology Autoimmune disease integumentary system business.industry fungi Autoantibody Dacryoadenitis Middle Aged medicine.disease Immune complex 030104 developmental biology Immunoglobulin G Immunology Female business Vasculitis Biomarkers |
| Zdroj: | Modern Rheumatology. 26:248-250 |
| ISSN: | 1439-7609 1439-7595 |
| DOI: | 10.3109/14397595.2015.1072296 |
| Popis: | IgG4-related disease (IgG4-RD) is characterized by various serological abnormalities. Some patients with IgG4-RD present with hypergammaglobulinemia, hypocomplementemia, and autoantibodies recognizing rheumatoid factors and nuclear factors. However, whether IgG4-RD is an autoimmune disease remains unclear.Here, we used immune complexome analysis to comprehensively identify constituent antigens of circulating immune complexes isolated from 10 patients with IgG4-related dacryoadenitis and/or sialadenitis (IgG4-RDS) which is one condition associated with IgG4-RD.We detected each of 125 distinct antigens in independent samples from two or more patients with IgG4-RDS. Of them, 17 antigens were found to be specific to patients with IgG4-RDS by comparing 125 antigens with all the antigens found in other connective tissue diseases (antineutrophil cytoplasmic antibody-associated vasculitis, Takayasu's arteritis, mixed connective tissue disease, dermatomyositis, Sjögren's syndrome, systemic scleroderma, and systemic lupus erythematosus) or healthy donors. The number of disease-specific antigens associated with IgG4-RDS was comparable to those autoimmune diseases.Studies of the 17 IgG4-RDS-specific antigens might lead to a better understanding of the pathogenesis of IgG4-RD, but further study of the prevalence of these CIC-associated antigens that involves a selective and sensitive assay will be needed to determine their potential as diagnostic or pathogenic biomarkers. |
| Databáze: | OpenAIRE |
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