Association study between SNP rs150689919 in the DNA demethylation gene, TET1, and Parkinson’s disease in Chinese Han population
| Autor: | Xinxiang Yan, Yingying Luo, Jifeng Guo, Lu Shen, Kai Li, Beisha Tang, Xinxin Liao, Kun Xia, Junling Wang, Zi-xiong Zhan |
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| Jazyk: | angličtina |
| Předmět: |
Adult
Male Adolescent Genotype Population Clinical Neurology Single-nucleotide polymorphism Polymorphism Single Nucleotide Mixed Function Oxygenases Young Adult Asian People Gene Frequency Proto-Oncogene Proteins Humans SNP Medicine Genetic Predisposition to Disease Child education Allele frequency Genotyping Genetic Association Studies Exome sequencing Aged Aged 80 and over Genetics education.field_of_study Chinese Chi-Square Distribution business.industry Parkinson Disease General Medicine DNA Methylation Middle Aged TET1 DNA-Binding Proteins DNA demethylation Parkinson’s disease Epigenetics Female Neurology (clinical) business Research Article |
| Zdroj: | BMC Neurology |
| ISSN: | 1471-2377 |
| DOI: | 10.1186/1471-2377-13-196 |
| Popis: | Background Recent studies suggest that epigenetic factors may play an important role in the pathogenesis of Parkinson’s disease (PD). In our previous work, we sequenced the exomes of sixteen patients from eight Chinese PD families using whole exome sequencing technology, consequently three patients from different pedigrees were found sharing the variant c.1460C > T (rs150689919) in the coding region of the Tet methyl cytosine dioxygenase 1 (TET1) gene. Methods In order to evaluate the possible association between sporadic PD and the single nucleotide polymorphism (SNP) rs150689919 in TET1, a case–control cohort study was conducted in 514 sporadic PD patients and 529 normal controls. Genotyping was determined by PCR and direct sequencing. Statistical significance was analyzed by the Chi-squared test. Results There was no statistical significance in TET1 rs150689919 genotype or allele frequencies between the PD cases and healthy controls, even after being stratified by gender and age at onset. Conclusions Our findings suggest that rs150689919 in TET1 may not be associated with PD in Chinese population. However, due to the limited data in this study, replication studies in larger sample and other populations are required. |
| Databáze: | OpenAIRE |
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