DDC- and 3TC-bis(SATE) Monophosphate Prodrugs Overcome Cellular Resistance Mechanisms to HIV-1 Associated with Cytidine Kinase Deficiency
| Autor: | B. Gröschel, N. Himmel, J. Cinatl, C. Périgaud, G. Gosselin, J-L. Imbach, H. W. Doerr |
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| Rok vydání: | 1999 |
| Předmět: |
Human immunodeficiency virus (HIV)
medicine.disease_cause Biochemistry Cell Line Uridine kinase Zalcitabine Deoxycytidine Kinase Genetics medicine Humans Cytotoxic T cell Prodrugs DNA Primers Base Sequence integumentary system Reverse Transcriptase Polymerase Chain Reaction Chemistry fungi Lamivudine Drug Resistance Microbial Deoxycytidine kinase Prodrug Cell culture HIV-1 Cancer research medicine.drug |
| Zdroj: | Nucleosides and Nucleotides. 18:921-926 |
| ISSN: | 0732-8311 |
| Popis: | A 2',3'-dideoxycytidine (ddC)-resistant T-lymphoid cell line (MOLT-4/8rddC250), in which deoxycytidine kinase (dCK) gene-expression was decreased when compared with parental cells, has been selected. Cytotoxic and antiretroviral activity of ddC and 3TC was significantly lower in MOLT-4/8rddC250-than in parental MOLT-4/8 cells. ddC- and 3TC-bis(SATE)phosphotriesters completely overcame cellular resistance mechanisms and showed comparable both cytotoxic and antiretroviral activity in parental and ddC-resistant cells. |
| Databáze: | OpenAIRE |
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