Terezine derivatives from the fungus Phoma herbarum PSU-H256
| Autor: | Jariya Sakayaroj, Vatcharin Rukachaisirikul, Wimarak Poonsuwan, Patchreenart Saparpakorn, Athip Maha, Supa Hannongbua, Saowanit Saithong, Souwalak Phongpaichit |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Stereochemistry
medicine.drug_class Phoma herbarum Plant Science Fungus Horticulture Crystallography X-Ray 010402 general chemistry Antimycobacterial 01 natural sciences Biochemistry Terezine E Ascomycota medicine Molecular Biology Molecular Structure biology 010405 organic chemistry Euphorbiaceae Absolute configuration General Medicine biology.organism_classification 0104 chemical sciences Pyrazines Hevea brasiliensis Oligopeptides |
| Zdroj: | Phytochemistry. 122:223-229 |
| ISSN: | 0031-9422 |
| DOI: | 10.1016/j.phytochem.2015.11.009 |
| Popis: | Investigation of the fungus Phoma herbarum PSU-H256 isolated from a leaf of Hevea brasiliensis resulted in the isolation of eight terezine derivatives (E-L) together with four known compounds. Their structures were established by analysis of spectroscopic evidence. For terezines E and H, their structures were confirmed by single-crystal X-ray diffraction crystallography. In addition, the absolute configuration at C-7 in terezine E was established by Mosher's method. Terezines K and L were tested for antibacterial, antimalarial, antimycobacterial and cytotoxic activities, but were inactive. |
| Databáze: | OpenAIRE |
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