Growth Hormone Stimulates the Selective Trafficking of Thymic CD4+CD8– Emigrants to Peripheral Lymphoid Organs
| Autor: | Marilza Moura Ribeiro-Carvalho, Mireille Dardenne, Salete Smaniotto, Valeria de Mello-Coelho, Wilson Savino |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
CD4-Positive T-Lymphocytes
medicine.medical_specialty Lymphoid Tissue Neuroimmunomodulation T cell Immunology Integrin Thymus Gland CD8-Positive T-Lymphocytes Integrin alpha4beta1 Growth hormone Mice Endocrinology Cell Movement Internal medicine medicine Animals L-Selectin Mice Inbred BALB C biology Endocrine and Autonomic Systems Cell movement Peripheral Cell biology Lymphatic system medicine.anatomical_structure Neurology Growth Hormone biology.protein Female L-selectin CD8 |
| Zdroj: | Neuroimmunomodulation. 11:299-306 |
| ISSN: | 1423-0216 1021-7401 |
| DOI: | 10.1159/000079410 |
| Popis: | Growth hormone (GH) has been shown to stimulate T cell development. However, its mechanisms of action on the peripheral T cell pool remain unknown. To address this question, intrathymic injection of GH in combination with fluorescein isothiocyanate (FITC) was used to assess the effects of GH on T cell trafficking from the thymus to the periphery. GH promoted a significant increase in the percentage and differential distribution of thymic CD4+CD8–FITC+ cells in secondary lymphoid organs. A significantly higher percentage of CD4+CD8–FITC+ cells was observed in the lymph nodes, while a relative decrease of these cells was found in the spleen. Moreover, we verified that GH treatment resulted in increased numbers of CD62L+CD4+CD8–FITC+ T cells in the lymph nodes, while the same treatment resulted in a decline in the percentage of VLA-6+CD4+CD8–FITC+ T cells in the spleen. Together, these findings suggest that GH is a potent immunoregulatory molecule which selectively stimulates the preferential homing of CD4+CD8– thymic emigrants to the subcutaneous lymph nodes possibly via the differential expression of CD62L and VLA-6. |
| Databáze: | OpenAIRE |
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