The effect of hirudin on endotoxin induced disseminated intravascular coagulation (DIC)
| Autor: | A. Ishikawa, Hafter R, U. Seemüller, Graeff H, J.M. Gokel |
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| Rok vydání: | 1980 |
| Předmět: |
Macromolecular Substances
Thrombin Time Antithrombin III Hirudin Pharmacology Fibrinogen Leukocyte Count medicine Animals Platelet Urinary output Disseminated intravascular coagulation Fibrin Platelet Count business.industry Antithrombin Hematology Disseminated Intravascular Coagulation Hirudins medicine.disease Endotoxins Generalized Shwartzman reaction Coagulation Immunology Female Rabbits business medicine.drug |
| Zdroj: | Thrombosis Research. 19:351-358 |
| ISSN: | 0049-3848 |
| DOI: | 10.1016/0049-3848(80)90263-7 |
| Popis: | The inhibitory effect of hirudin was investigated in rabbits, which developed the generalized Shwartzman reaction after two endotoxin injections spaced 24 hours apart. Hirudin was infused for a period of 6 hrs after the second endotoxin injection. In the controls glomerular microthrombosis and reduced urinary output were associated with laboratory signs of intravascular coagulation such as decrease of fibrinogen, antithrombin III, platelets, leukocytes, and an increase of high molecular weight derivatives of fibrinogen. Hirudin infusion prevented acute renal failure and glomerular microthrombosis in ten of twelve animals and consumption of coagulation factors. The decrease of platelets was also reduced while the decrease of leukocytes was unaffected. The findings indicate that the hematological and functional consequences of the GSR can be prevented by infusion of hirudin. |
| Databáze: | OpenAIRE |
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