A genome-wide family-based linkage study of coeliac disease
| Autor: | Harold Ellis, M.-A. Morris, A. M. Dearlove, David Curtis, Paul J. Ciclitira, M. Rhodes, A L King, J. Y. Yiannakou, Christopher G. Mathew, Peter Brett, S. Rosen-Bronson |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Immunoconjugates Genetic Linkage Population Pedigree chart Biology Genome Genetic determinism Abatacept Genetic linkage Antigens CD Genetics Humans CTLA-4 Antigen education Genetics (clinical) Linkage (software) education.field_of_study Chromosomes Human Pair 10 Genome Human Genes T-Cell Receptor gamma Antigens Differentiation Pedigree Celiac Disease Microsatellite Human genome DNA Intergenic Female Lod Score Chromosomes Human Pair 16 Microsatellite Repeats |
| Zdroj: | Annals of human genetics. 64(Pt 6) |
| ISSN: | 0003-4800 |
| Popis: | The susceptibility to develop coeliac disease (CD) has a strong genetic component, which is not entirely explained by HLA associations. Two previous genome wide linkage studies have been performed to identify additional loci outside this region. These studies both used a sib-pair design and produced conflicting results. Our aim is to identify non-MHC genetic loci contributing to coeliac disease using a family based linkage study. We performed a genome wide search in 16 highly informative multiply affected pedigrees using 400 microsatellite markers with an average spacing of 10 cM. Linkage analysis was performed using lod score and model free methods. We identified two new potential susceptibility loci with lod scores of 1.9, at 10q23.1, and 16q23.3. Significant, but lower lod scores were found for 6q14 (1.2), 11p11 (1.5), and 19q13.4 (0.9), areas implicated in a previous genome wide study. Lod scores of 0.9 were obtained for both D78507, which lies 1 cM from the gammaT-cell receptor gene, and for D2S364, which lies 12 cM from the CTLA4 gene. |
| Databáze: | OpenAIRE |
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