Prevalence of Crimean-Congo Hemorrhagic Fever Virus among Livestock and Ticks in Zhambyl Region, Kazakhstan, 2017

Autor: Jonathan Bryant-Genevier, Yekaterina Bumburidi, Lilit Kazazian, Victoria Seffren, Jennifer R. Head, Dmitriy Berezovskiy, Bakhytkul Zhakipbayeva, Stephanie J. Salyer, Barbara Knust, John D. Klena, Cheng-Feng Chiang, Gulfaira Mirzabekova, Kumisbek Rakhimov, Jandar Koekeev, Kanatbek Kartabayev, Seydigapbar Mamadaliyev, Marta Guerra, Curtis Blanton, Trevor Shoemaker, Daniel Singer, Daphne B. Moffett
Rok vydání: 2022
Předmět:
Zdroj: Am J Trop Med Hyg
ISSN: 1476-1645
0002-9637
DOI: 10.4269/ajtmh.21-1092
Popis: Crimean-Congo hemorrhagic fever (CCHF) is a highly fatal zoonotic disease endemic to Kazakhstan. Previous work estimated the seroprevalence of CCHF virus (CCHFV) among livestock owners in the Zhambyl region of southern Kazakhstan at 1.2%. To estimate CCHFV seroprevalence among cattle and sheep, we selected 15 villages with known history of CCHFV circulation (endemic) and 15 villages without known circulation (nonendemic) by cluster sampling with probability proportional to livestock population size. We collected whole blood samples from 521 sheep and 454 cattle from randomly selected households within each village and collected ticks found on the animals. We tested livestock blood for CCHFV-specific IgG antibodies by ELISA; ticks were screened for CCHFV RNA by real-time reverse transcription polymerase chain reaction and CCHFV antigen by antigen-capture ELISA. We administered questionnaires covering animal demographics and livestock herd characteristics to an adult in each selected household. Overall weighted seroprevalence was 5.7% (95% CI: 3.1, 10.3) among sheep and 22.5% (95% CI: 15.8, 31.2) among cattle. CCHFV-positive tick pools were found on two sheep (2.4%, 95% CI: 0.6, 9.5) and three cattle (3.8%, 95% CI: 1.2, 11.5); three CCHFV-positive tick pools were found in nonendemic villages. Endemic villages reported higher seroprevalence among sheep (15.5% versus 2.8%, P < 0.001) but not cattle (25.9% versus 20.1%, P = 0.42). Findings suggest that the current village classification scheme may not reflect the geographic distribution of CCHFV in Zhambyl and underscore that public health measures must address the risk of CCHF even in areas without a known history of circulation.
Databáze: OpenAIRE
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