Dynamics of 2-N-tert-butylaminoxyladenosine incorporated into oligodeoxynucleotides

Autor: Hiroshi Suemune, John Walter Mirc, Noboru Koga, Toshiyuki Kaneko, Yoshitaka Higuchi, Manami Kurita, Mariko Aso
Rok vydání: 2008
Předmět:
Zdroj: Nucleic acids symposium series (2004). (52)
ISSN: 1746-8272
Popis: We synthesized oligodeoxynucleotide (ODN, 3) containing 2-N-tert-butylaminoxyladenosine (1) and studied EPR spectra of 1 and its duplexes with varied sequences. Duplex formation resulted in a broadening of spectrum and a significant decrease in peak-to-peak height and peak height ratio values. The h(+)/ho values in EPR spectra well correlated with stability of duplex which indicated ODN containing 1 has the potential to monitor DNA structure.
Databáze: OpenAIRE