Maternal Hypothyroidism and Fetal Chondro-Osseous Development in Rats
| Autor: | G. Morreale de Escobar, María Jesús Obregón, R. Gil-Garay, E. Delgado-Baeza, F. Escobar Del Rey, C. Miralles-Flores |
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| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Bone development medicine.medical_treatment Gestational Age Biology Maternal hypothyroidism Rat fetus Hypothyroidism Pregnancy Internal medicine medicine Animals reproductive and urinary physiology Fetus Bone Development Fetal Growth Retardation Body Weight Thyroidectomy Rats Inbred Strains medicine.disease Rats Pregnancy Complications Endocrinology embryonic structures Pediatrics Perinatology and Child Health Gestation Female Developmental Biology |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1661-7819 1661-7800 |
| DOI: | 10.1159/000243437 |
| Popis: | The bone development of rat fetuses from female Wistar rats thyroidectomized prior to mating was studied, between 16 and 21 days of gestation. The parameters studied in each rat fetus were fetal weight, number of fetuses per litter, radiological data and frequency of appearance of ossification centers, diaphyseal radiological length of long bones, longitudinal ratio between epiphysis and diaphysis of long bones on cleaned and stained limbs, and volumetric tibial studies on the same limbs. Our results show a delay of fetal chondro-osseous development and a delay of weight increase in fetuses from thyroidectomized rats. After onset of fetal thyroid function, the fetal development begins a catch-up growth, which is not sufficient to completely overcome developmental delay prior to birth. |
| Databáze: | OpenAIRE |
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