Prevalence and Determinants of Agonistic Autoantibodies Against α1-Adrenergic Receptors in Patients Screened Positive for Dementia: Results from the Population-Based DelpHi-Study

Autor: Hans J. Grabe, Marion Bimmler, Johannes Hertel, Jochen René Thyrian, Rudolf Kunze, Marcus Dörr, Stefan J. Teipel, Harald Prüss, Wolfgang Hoffmann, Petra Hempel, Lara N. Schulze
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
immunology [Receptors
Adrenergic
alpha-1]
medicine.medical_specialty
Psychometrics
epidemiology [Dementia]
Severity of Illness Index
Community Health Planning
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Receptors
Adrenergic
alpha-1
Internal medicine
Severity of illness
medicine
Humans
Dementia
ddc:610
Aged
Autoantibodies
Aged
80 and over
Psychiatric Status Rating Scales
immunology [Receptors
Adrenergic
beta-2]
biology
business.industry
General Neuroscience
Medical record
Autoantibody
General Medicine
medicine.disease
blood [Dementia]
Psychiatry and Mental health
Clinical Psychology
Logistic Models
030104 developmental biology
Cohort
biology.protein
Biomarker (medicine)
blood [Autoantibodies]
Female
Receptors
Adrenergic
beta-2
Geriatrics and Gerontology
Antibody
business
030217 neurology & neurosurgery
Cohort study
Zdroj: Journal of Alzheimer's disease 64(4), 1091-1097 (2018). doi:10.3233/JAD-171096
ISSN: 1875-8908
1387-2877
DOI: 10.3233/jad-171096
Popis: Background There is a need to assess promising biomarkers for diagnosis and treatment response in real-life settings. Despite the important role of vascular risk factors, cardiovascular biomarkers have played a minor role in dementia research. Agonistic autoantibodies (agAAB) directed against G-protein-coupled receptors (GPCR) are discussed as modulators of pathology and clinical manifestation. Objective 1) Describe prevalence of agAAB directed against GPCR, especially agABB against α1-adrenergic receptors (α1-AR-agAAB) and agABB directed against β2-adrenergic receptors (β2-AR-agAAB) and 2) identify factors associated with agAAB in people with dementia during routine care. Methods Blood samples and data from 95 subjects who screened positive for dementia from a primary care cohort, analyzed using an enzyme-linked immunosorbent assay (ELISA) for detecting agAAB. Sociodemographic and clinical data were assessed, and medical records checked. Results In 40 (42%) samples, agAAB was detected, with n = 29 (31%) representing α1-AR-agAAB and n = 21 (22%) β2-AR-agAAB. There was no association between the presence of any antibody and a formal diagnosis of dementia. However, patients with coronary heart disease were more likely (OR = 4.23) to have α1-AR-agAAB than those without coronary heart disease. There were no associations between agAAB and age, sex, education, or cognitive impairment. Discussion For the first time, we show that autoantibodies have a significant prevalence in people with dementia in a routine care setting. Previous findings were restricted to highly selective samples. We replicated the association between α1-AR-agAAB in patients with coronary heart diseases but were not able to find other factors associated with the presence of agAAB.
Databáze: OpenAIRE
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