Insights into the Immunopathogenesis of Multiple Sclerosis
| Autor: | Piet Stinissen, Niels Hellings, Jef Raus |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Central Nervous System
Encephalomyelitis Autoimmune Experimental Multiple Sclerosis T-Lymphocytes medicine.medical_treatment Immunology Central nervous system Receptors Antigen T-Cell T-cell vaccination Autoimmunity Biology Lymphocyte Activation Autoantigens Myelin Immune system Antigen medicine Animals Humans HLA-DR2 Antigen Myelin Sheath Autoimmune disease Multiple sclerosis Vaccination Models Immunological Immunotherapy medicine.disease medicine.anatomical_structure Cytokines Inflammation Mediators |
| Zdroj: | Immunologic Research. 25:27-52 |
| ISSN: | 0257-277X |
| DOI: | 10.1385/ir:25:1:27 |
| Popis: | Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Significant progress has been made in our understanding of the etiology of MS. MS is widely believed to be an autoimmune disease that results from aberrant immune responses to CNS antigens. T cells are considered to be crucial in orchestrating an immunopathological cascade that results in damage to the myelin sheath. This review summarizes the currently available data supporting the idea that myelin reactive T cells are actively involved in the immunopathogenesis of MS. Some of the therapeutic strategies for MS are discussed with a focus on immunotherapies that aim to specifically target the myelin reactive T cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink