Effects of amlodipine on baroreflex and sympathetic nervous system activity in mild-to-moderate hypertension
| Autor: | F. Tremel, Jean Philippe Baguet, Siché Jp, Daniel Fagret, Régis de Gaudemaris, Jean-Michel Mallion |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Sympathetic nervous system Sympathetic Nervous System Adolescent Adrenergic Blood Pressure Baroreflex Essential hypertension Catecholamines Double-Blind Method Heart Rate Internal medicine Heart rate Internal Medicine medicine Humans Amlodipine Antihypertensive Agents Aged business.industry Middle Aged medicine.disease Blood pressure medicine.anatomical_structure Endocrinology Hypertension Catecholamine Female Receptors Adrenergic beta-2 business medicine.drug |
| Zdroj: | American Journal of Hypertension. 14:424-428 |
| ISSN: | 0895-7061 |
| DOI: | 10.1016/s0895-7061(00)01258-9 |
| Popis: | To investigate the effect of amlodipine on baroreflex sensitivity and sympathetic system activity, 36 patients with essential hypertension were randomized to once-daily, double-blind treatment with amlodipine 5 mg or placebo 5 mg for 60 days. Measurements with a Finapres device allowed calculation of baroreflex sensitivity and blood pressure (BP) variability. Adrenergic activity was assessed via measurements of lymphocyte β2-adrenoceptors and plasma catecholamine concentrations. Compared with placebo, amlodipine significantly decreased BP, but did not significantly alter baroreflex sensitivity. Spectral analysis of Finapres data showed that, compared with placebo, amlodipine decreased the variability of systolic blood pressure, diastolic blood pressure, and RR interval in the low frequency band. There were no simultaneous changes in adrenergic function, however, suggesting that these effects of amlodipine were not mediated via sympathetic nervous system activation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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