The Effect of Interferon-γ on Rejection and Neutrophil Function Following Transplantation
| Autor: | Slater Ad, Christine W. Czarniecki, Jon B. Klein, Gerald Sonnenfeld |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Graft Rejection
medicine.medical_specialty Transplantation Heterotopic Neutrophils Neutrophile medicine.medical_treatment Immunology Pharmacology Organ transplantation Interferon-gamma Interferon Virology Abdomen medicine Animals Drug Interactions Interferon gamma Respiratory Burst Chemotherapy business.industry Immunotherapy Recombinant Proteins Rats Rats Inbred ACI Respiratory burst Transplantation Rats Inbred Lew Cyclosporine Heart Transplantation business medicine.drug |
| Zdroj: | Journal of Interferon Research. 13:359-362 |
| ISSN: | 0197-8357 |
| Popis: | Rats were used as a model for a living heterotopic cardiac allograft organ transplant. Rats treated in this model with recombinant rat interferon-gamma (IFN-gamma) showed accelerated rejection in a dose-dependent fashion. However, rats treated with maintenance doses of cyclosporine and IFN-gamma expressed increased rejection at 20 days that had resolved completely by 45 days post-transplantation. Polymorphonuclear leukocytes (neutrophils) were isolated from the blood of rats, and their function was determined by treating the cells with f-Met-Leu-Phe (fMLP) and measuring superoxide produced. Results indicate that the neutrophils from rats treated with maintenance doses of cyclosporine and IFN-gamma still had increased IFN-gamma-modulated fMLP-induced respiratory burst and that maintenance cyclosporine therapy can inhibit the IFN-gamma-mediated accelerated rejection without compromising the antimicrobial effects of IFN-gamma treatment. |
| Databáze: | OpenAIRE |
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