Thyroid function in children with short stature accompanied by isolated pituitary hypoplasia
| Autor: | Qiang Liu, Guimei Li, Liping Zhu, Yongzhen Xue, Xuemei Sun, Yanyan Hu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Human Growth Hormone Endocrinology Diabetes and Metabolism Area under the curve Thyroid Gland Retrospective cohort study General Medicine Control subjects Short stature Gastroenterology Body Height Internal medicine Pituitary hypoplasia Medicine IGHD Humans medicine.symptom Thyroid function Insulin-Like Growth Factor I business Child Dwarfism Pituitary Growth Disorders Hormone |
| Zdroj: | Hormones (Athens, Greece). 20(4) |
| ISSN: | 2520-8721 |
| Popis: | Few studies have focused on thyroid function in children with isolated pituitary hypoplasia (IPH). The purpose of this study was to investigate thyroid function in children with short stature accompanied by IPH and evaluate the values of thyroid function for the diagnosis of IPH. This was a retrospective observational study. A total of 100 children with short stature accompanied by IPH were enrolled. Among them, 68 children presenting with isolated growth hormone deficiency (IGHD) were chosen as the IPH group. Sixty-eight age-matched and sex-matched IGHD children without pituitary abnormalities were chosen as the control group. Clinical, hormonal, and imaging parameters were analyzed. The diagnostic value of thyroid function for IGHD children with IPH was evaluated. Children in the IPH group had significantly lower height standard deviation score (HSDS), HSDS-target height standard deviation score (THSDS), free thyroxine (FT4), insulin-like growth factor-1 standard deviation score (IGF-1SDS), and pituitary height than the control subjects (p = 0.027, p = 0.033, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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