Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats

Autor:	Azeddine Ibrahimi, Landa, St Lezin Em, Ludmila Kazdova, Alena Musilova, Theodore W. Kurtz, Zídek, N. Qi, Anne M. Glazier, Timothy J. Aitman, Nada A. Abumrad, Kren, M Pravenec, J M Wang
Rok vydání:	2001
Předmět:	CD36 Antigens medicine.medical_specialty Transgene medicine.medical_treatment CD36 Biology Animals Genetically Modified Insulin resistance Rats Inbred SHR Internal medicine Gene expression Genetics medicine Animals cardiovascular diseases Glucose tolerance test medicine.diagnostic_test Insulin Fatty Acids Metabolism Glucose Tolerance Test medicine.disease Rats Genetically modified organism Endocrinology Hypertension cardiovascular system biology.protein Insulin Resistance circulatory and respiratory physiology
Zdroj:	Nature Genetics. 27:156-158
ISSN:	1546-1718 1061-4036
Popis:	Spontaneously hypertensive rats (SHR) display several features of the human insulin-resistance syndromes. Cd36 deficiency is genetically linked to insulin resistance in SHR. We show that transgenic expression of Cd36 in SHR ameliorates insulin resistance and lowers serum fatty acids. Our results provide direct evidence that Cd36 deficiency can promote defective insulin action and disordered fatty-acid metabolism in spontaneous hypertension.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf62d402027c9be2d4abe5824c5dc7a https://doi.org/10.1038/84777 Zobrazit plný text záznamu Plný text ve formátu PDF